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Dr. Emmanuel Bouvier

Welcome to my personal webpage !!

In this site, you'll find background information about me and my education, various photographs, and updated informations.


Resume: Doctor in Medicinal,Organic and Bio-organic Chemistry

PROFESSIONAL EXPERIENCE

 
  
 2005

Sanofi-Aventis (Montpellier): Responsable de laboratoire au sein  du Développement Chimique. Développement préclinique de principes actifs : adaptation voie discovery et nouvelles voies de synthèse, faisabilité, optimisation, scale-up. Suivi de projet, coordination avec le kilolab.

  
2004-2005Postdoctoral position in Drexel University College of Medicine under the supervision of Dr Graham Ellis-Davies : Conception and synthesis of caged compounds with good photochemical properties, specially 2-photons cross-section. Application for the caging of neurotransmitters (GABA, glutamate), ATP, ARN. Utilisation of HPLC and of a 2-photons laser coupled with an imaging laser for in vitro experiments on cells.
  
19993.5 monthsAventis (ex Hoechst-Marion-Roussel AG), Frankfürt (Germany):Pharmaceutical research laboratory for studies of potassium-dependant channel blockers. Synthesis and purification of active compounds for animal tests.
  
19981.5 monthLaboratory of Molecular Electrochemistry, U. Paris VII Diderot, Pr Saveant: Fundamental studies of bioorganic systems. Grafting of pegylated Ferrocene on a glassy carbon electrode for new specific electrodes ; cyclic voltammetric studies.
  
EDUCATION 
2000-2003PhD in Institut Curie under the supervision of Dr Claude Monneret: Conception, synthesis and primary biological evaluations of glucuronated prodrugs of Taxol and Taxotere. This implied a strong work on the bench with full multi-steps synthesis of spacers and handling of the drugs, and knowledge in the field of antitumor targeting (ADEPT, PMT).
  
1997-20001999-2000Graduate engineer of Chemistry College in Rennes (ENSCR).Masters (73%) in organic chemistry Synthèse et Production, U. Rennes I.
  

Languages

&

Information Skills
· French: mother tongue· English: fluent

·German: working knowledge (e.g. for reading articles)

 Word, PowerPoint, literature searching tools (Beilstein, SciFinder, internet).

 

Publications

Posters

· IIIrd Scientific Congress of Paris Students, Paris, April 26-27 2001:

ADEPT strategy: synthesis and biological evaluation of a paclitaxel prodrug.

· 39th International Meeting of Medicinal Chemistry, 2nd Joint French-Swiss Meeting on Medicinal Chemistry, Beaune, France, July 1-4 2003:

Synthesis and Biological Studies of a new Paclitaxel Prodrug.

 

Oral Presentation

7th Journée of Organic Chemistry and Organic-Biologic Chemistry of Montagne-Sainte-Geneviève, Paris, May 16 2003:

Synthesis and Biological Studies of a new Paclitaxel Prodrug.

 

Articles

· Bouvier E., Thirot S., Schmidt F. and Monneret C. ; A new paclitaxel prodrug for use in ADEPT strategy, Organic and Biomolecular Chemistry 2003, 1, p3343-3352.

 

· Bouvier E., Thirot S., Schmidt F. and Monneret C. ; First enzymatically activated Taxotere prodrugs designed for ADEPT and PMT, Bioorganic Medicinal Chemistry 2004, 12, p969-977.

Interests

Hobbies:

Culture pastimes (museums, exhibitions, reading specially classical authors and science fiction), cooking, hiking and picking up mushrooms.

Sports:

Soccer, gaelic football, moutain bike, nordic skiing.

emmanuel_bouvier@yahoo.fr