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Dr. Emmanuel Bouvier
Welcome to my personal webpage !!
In this site, you'll find background information about me and my education, various photographs, and updated informations.
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Resume: Doctor in Medicinal,Organic and Bio-organic Chemistry
PROFESSIONAL EXPERIENCE | | | | 2005 | Sanofi-Aventis (Montpellier): Responsable de laboratoire au sein du Développement Chimique. Développement préclinique de principes actifs : adaptation voie discovery et nouvelles voies de synthèse, faisabilité, optimisation, scale-up. Suivi de projet, coordination avec le kilolab. | | | 2004-2005 | Postdoctoral position in Drexel University College of Medicine under the supervision of Dr Graham Ellis-Davies : Conception and synthesis of caged compounds with good photochemical properties, specially 2-photons cross-section. Application for the caging of neurotransmitters (GABA, glutamate), ATP, ARN. Utilisation of HPLC and of a 2-photons laser coupled with an imaging laser for in vitro experiments on cells. | | | 19993.5 months | Aventis (ex Hoechst-Marion-Roussel AG), Frankfürt (Germany):Pharmaceutical research laboratory for studies of potassium-dependant channel blockers. Synthesis and purification of active compounds for animal tests. | | | 19981.5 month | Laboratory of Molecular Electrochemistry, U. Paris VII Diderot, Pr Saveant: Fundamental studies of bioorganic systems. Grafting of pegylated Ferrocene on a glassy carbon electrode for new specific electrodes ; cyclic voltammetric studies. | | | EDUCATION | | 2000-2003 | PhD in Institut Curie under the supervision of Dr Claude Monneret: Conception, synthesis and primary biological evaluations of glucuronated prodrugs of Taxol and Taxotere. This implied a strong work on the bench with full multi-steps synthesis of spacers and handling of the drugs, and knowledge in the field of antitumor targeting (ADEPT, PMT). | | | 1997-20001999-2000 | Graduate engineer of Chemistry College in Rennes (ENSCR).Masters (73%) in organic chemistry Synthèse et Production, U. Rennes I. | | | Languages &Information Skills | · French: mother tongue· English: fluent ·German: working knowledge (e.g. for reading articles) | | Word, PowerPoint, literature searching tools (Beilstein, SciFinder, internet). |
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Publications
Posters |
· IIIrd Scientific Congress of Paris Students, Paris, April 26-27 2001:
ADEPT strategy: synthesis and biological evaluation of a paclitaxel prodrug. |
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· 39th International Meeting of Medicinal Chemistry, 2nd Joint French-Swiss Meeting on Medicinal Chemistry, Beaune, France, July 1-4 2003:
Synthesis and Biological Studies of a new Paclitaxel Prodrug. |
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Oral Presentation |
7th Journée of Organic Chemistry and Organic-Biologic Chemistry of Montagne-Sainte-Geneviève, Paris, May 16 2003:
Synthesis and Biological Studies of a new Paclitaxel Prodrug. |
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Articles |
· Bouvier E., Thirot S., Schmidt F. and Monneret C. ; A new paclitaxel prodrug for use in ADEPT strategy, Organic and Biomolecular Chemistry 2003, 1, p3343-3352. |
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· Bouvier E., Thirot S., Schmidt F. and Monneret C. ; First enzymatically activated Taxotere prodrugs designed for ADEPT and PMT, Bioorganic Medicinal Chemistry 2004, 12, p969-977. |
Interests
Hobbies: Culture pastimes (museums, exhibitions, reading specially classical authors and science fiction), cooking, hiking and picking up mushrooms. Sports: Soccer, gaelic football, moutain bike, nordic skiing.
emmanuel_bouvier@yahoo.fr |
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